Protein Family Models

This entry represents the HTH domains found in siroheme decarboxylase NirdL from Hydrogenobacter thermophilus and related sequences [5]. NirdL is involved in heme d1 biosynthesis. It catalyses the decarboxylation of siroheme into didecarboxysiroheme. Paper describing PDB structure 1i1g. [1]. 11230123. Crystal structure of the Lrp-like transcriptional regulator from the archaeon Pyrococcus furiosus. Leonard PM, Smits SH, Sedelnikova SE, Brinkman AB, de Vos WM, van der Oost J, Rice DW, Rafferty JB;. EMBO J. 2001;20:990-997. Paper describing PDB structure 1ri7. [2]. 14976242. The archaeal feast/famine regulatory protein: potential roles of its assembly forms for regulating transcription. Koike H, Ishijima SA, Clowney L, Suzuki M;. Proc Natl Acad Sci U S A. 2004;101:2840-2845. Paper describing PDB structure 2l4a. [3]. 21338611. The design involved in PapI and Lrp regulation of the pap operon. Kawamura T, Vartanian AS, Zhou H, Dahlquist FW;. J Mol Biol. 2011;409:311-332. Paper describing PDB structure 2zny. [4]. 19004003. Interactions between the archaeal transcription repressor FL11 and its coregulators lysine and arginine. Yamada M, Ishijima SA, Suzuki M;. Proteins. 2009;74:520-525. Paper describing PDB structure 4ch7. [5]. 25083922. The crystal structure of siroheme decarboxylase in complex with iron-uroporphyrin III reveals two essential histidine residues. Haufschildt K, Schmelz S, Kriegler TM, Neumann A, Streif J, Arai H, Heinz DW, Layer G;. J Mol Biol. 2014;426:3272-3286. (from Pfam)

Date:

2024-10-16

This entry contains an AsnC-like ligand binding domain. [1]. 24865947. The structure, function and properties of sirohaem decarboxylase--an enzyme with structural homology to a transcription factor family that is part of the alternative haem biosynthesis pathway. Palmer DJ, Schroeder S, Lawrence AD, Deery E, Lobo SA, Saraiva LM, McLean KJ, Munro AW, Ferguson SJ, Pickersgill RW, Brown DG, Warren MJ;. Mol Microbiol. 2014;93:247-261. (from Pfam)

Date:

2024-10-16

Date:

2024-08-14