Protein Family Models

Formylglutamate amidohydrolase (FGase) catalyses the terminal reaction in the five-step pathway for histidine utilisation in Pseudomonas putida. By this action, N-formyl-L-glutamate (FG) is hydrolysed to produce L-glutamate plus formate [1]. [1]. 3308850. Purification and properties of formylglutamate amidohydrolase from Pseudomonas putida. Hu L, Mulfinger LM, Phillips AT;. J Bacteriol 1987;169:4696-4702. (from Pfam)

Date:

2024-10-16

In some species, histidine is converted to via urocanate and then formimino-L-glutamate to glutamate in four steps, where the fourth step is conversion of N-formimino-L-glutamate to L-glutamate and formamide. In others, that pathway from formimino-L-glutamate may differ, with the next enzyme being formiminoglutamate hydrolase (HutF) yielding N-formyl-L-glutamate. This HMM represents the enzyme N-formylglutamate deformylase, also called N-formylglutamate amidohydrolase, which then produces glutamate.

Gene:

hutG

Date:

2021-04-27