Protein Family Models

Members of this family include both GspH, from type II secretion systems (T2SS), and pilin-like proteins (pseudopilins) of type IV pilus systems.

Date:

2024-10-16

This short motif directs methylation of the conserved phenylalanine residue. It is most often found at the N-terminus of pilins and other proteins involved in secretion, see Pfam:PF00114, Pfam:PF05946, Pfam:PF02501 and Pfam:PF07596. (from Pfam)

Date:

2024-08-14

GspH is one of four minor pseudopilins of the type II secretion system (T2SS), previously called the main terminal branch of the general secretion pathway (hence the gene symbol). The T2SS system does not depend on cell-cell contact for its secretion (it has no injectosome) of its targets, which include pullulanase from Klebsiella oxytoca, exotoxin A from Pseudomonas aeruginosa, protease VesB from Vibrio cholerae, etc.

Gene:

gspH

Date:

2021-05-12

type II secretion system protein similar to Pseudomonas aeruginosa type II secretion system protein H, which is involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins; required for the translocation of a variety of enzymes across the outer membrane; pilin similar to fimbrial protein PilE, which is required for pilus biogenesis, as well as fimbrial protein PilA, which is responsible for the adhesive property of the pilus

Date:

2024-08-08

This model describes many but not all examples of the N-terminal region of bacterial proteins that resemble type IV pilins at their N-terminus, with a cleavage site G^FxxxE followed by a hydrophobic stretch. The new N-terminal residue, usually Phe, is methylated. Separate domains of the prepilin peptidase appear responsible for cleavage and methylation. Proteins with this N-terminal region include type IV pilins and other components of pilus biogenesis, competence proteins, and type II secretion proteins. Typically several proteins in a single operon have this N-terminal domain. The N-terminal cleavage and methylation site is described by PROSITE motif PS00409 as [KRHEQSTAG]-G-[FYLIVM]-[ST]-[LT]-[LIVP]-E-[LIVMFWSTAG](14).

Date:

2019-09-10

XcpU is a lineage-specific alternative name, in Pseudomonas aeruginosa, for the type II secretion system (T2SS) minor pseudopilin component GspH (general secretory pathway H, from an older terminology).

Gene:

xcpU

Date:

2020-11-05