Protein Family Models

This domain is found at the N-terminus of bacterial reverse transcriptases. (from Pfam)

Date:

2024-08-14

This region is found mainly in various bacterial and archaeal species, but a few members of this family are expressed by fungal and chlamydomonal species. It has been implicated in the binding of intron RNA during reverse transcription and splicing [1]. [1]. 11959575. Presence of a group II intron in a multiresistant Serratia marcescens strain that harbors three integrons and a novel gene fusion. Centron D, Roy PH;. Antimicrob Agents Chemother 2002;46:1402-1409. (from Pfam)

Date:

2024-10-16

His-Asn-His (HNH) proteins are a very common family of small nucleic acid-binding proteins that are generally associated with endonuclease activity [4]. Named family as HNH. [1]. 7817395. Amino acid sequence motif of group I intron endonucleases is conserved in open reading frames of group II introns. Shub DA, Goodrich-Blair H, Eddy SR;. Trends Biochem Sci 1994;19:402-404. Extended HNH family. [2]. 9358175. Statistical modeling and analysis of the LAGLIDADG family of site-specific endonucleases and identification of an intein that encodes a site-specific endonuclease of the HNH family. Dalgaard JZ, Klar AJ, Moser MJ, Holley WR, Chatterjee A, Mian IS;. Nucleic Acids Res 1997;25:4626-4638. Named family as EX1HH-HX3H. [3]. 7920259. Self-splicing group I and group II introns encode homologous (putative) DNA endonucleases of a new family. Gorbalenya AE;. Protein Sci 1994;3:1117-1120. [4]. 27131500. Biochemical characterization of a thermostable HNH endonuclease from deep-sea thermophilic bacteriophage GVE2. Zhang L, Huang Y, Xu D, Yang L, Qian K, Chang G, Gong Y, Zhou X, Ma K;. Appl Microbiol Biotechnol. 2016;100:8003-8012. (from Pfam)

Date:

2024-10-16

A reverse transcriptase gene is usually indicative of a mobile element such as a retrotransposon or retrovirus. Reverse transcriptases occur in a variety of mobile elements, including retrotransposons, retroviruses, group II introns, bacterial msDNAs, hepadnaviruses, and caulimoviruses. [1]. 1698615. Origin and evolution of retroelements based upon their reverse transcriptase sequences. Xiong Y, Eickbush TH;. EMBO J 1990;9:3353-3362. (from Pfam)

Date:

2024-10-16

protein containing domains RVT_N, RT_G2_intron, and HNHc

Date:

2017-03-02

Members of this protein family are multifunctional proteins encoded in most examples of bacterial group II introns. These group II introns are mobile selfish genetic elements, often with multiple highly identical copies per genome. Member proteins have an N-terminal reverse transcriptase (RNA-directed DNA polymerase) domain (PF00078) followed by an RNA-binding maturase domain (PF08388). Some members of this family may have an additional C-terminal DNA endonuclease domain that this model does not cover. A region of the group II intron ribozyme structure should be detectable nearby on the genome by Rfam model RF00029.

Gene:

ltrA

Date:

2021-04-27