Protein Family Models

ESAT-6 is a small protein appears to be of fundamental importance in virulence and protective immunity in Mycobacterium tuberculosis. Homologues have been detected in other Gram-positive bacterial species. It may represent a novel secretion system potentially driven by the Pfam:PF01580 domains in the YukA-like proteins [1]. [1]. 11973144. The ESAT-6/WXG100 superfamily -- and a new Gram-positive secretion system?. Pallen MJ;. Trends Microbiol 2002;10:209-212. [2]. 15657139. EsxA and EsxB are secreted by an ESAT-6-like system that is required for the pathogenesis of Staphylococcus aureus infections. Burts ML, Williams WA, DeBord K, Missiakas DM;. Proc Natl Acad Sci U S A. 2005;102:1169-1174. [3]. 19674902. Outer membrane translocation: numerical protein secretion nomenclature in question in mycobacteria. Desvaux M, Hebraud M, Talon R, Henderson IR;. Trends Microbiol. 2009;17:338-340. [4]. 20852931. New insights into the distribution of WXG100 protein secretion systems. Sutcliffe IC;. Antonie Van Leeuwenhoek. 2011;99:127-131. [5]. 19299134. Secretion and subcellular localizations of bacterial proteins: a semantic awareness issue. Desvaux M, Hebraud M, Talon R, Henderson IR;. Trends Microbiol. 2009;17:139-145. (from Pfam)

Date:

2024-10-16

EsxE and EsxF form a water-soluble heterodimer (EsxEF) that assembles into oligomers and long filaments, binds to membranes, and forms stable membrane-spanning channels, which export the tuberculosis necrotizing toxin CpnT.

Gene:

esxE

Date:

2021-04-15

WXG100 family type VII secretion target such as mycobacterial ESAT-6-like protein EsxB, also called CFP-10, which is a secreted protein that acts as a strong host T-cell antigen and is involved in the translocation of bacteria from the host phagolysosome to the host cytoplasm

Date:

2020-06-24