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Acg family FMN-binding oxidoreductase
Paralogs Rv2032, Rv3131, and Rv3127 in Mycobacterium tuberculosis are recognizably homologous to classical nitroreductases (see Pfam model PF00881). Rv2032 is known as Acg (Acr-coregulated gene) because Rv2032 and Acr (Rv2031c) are both highly upregulated by DosR (dormancy survival regulator), a response regulator transcription factor involved in the response to hypoxia and to the macrophage intracellular environment. Rv3131 and Rv3127 likewise belong to the DosR regulon. MSMEG_3955 from Mycobacterium smegmatis, most closely related to Rv3131, was reported to be a trimeric NADPH-dependent FMN oxidoreductase, and to lack detectable nitroreductase activity.
FMN-binding protein Acg
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