Protein Family Models

This family includes the catalytic regions of the chorismate binding enzymes anthranilate synthase, isochorismate synthase, aminodeoxychorismate synthase and para-aminobenzoate synthase. [1]. 11371633. The structures of anthranilate synthase of Serratia marcescens crystallized in the presence of (i) its substrates, chorismate and glutamine, and a product, glutamate, and (ii) its end-product inhibitor, L-tryptophan. Spraggon G, Kim C, Nguyen-Huu X, Yee MC, Yanofsky C, Mills SE;. Proc Natl Acad Sci U S A 2001;98:6021-6026. [2]. 11450855. A metabolic node in action: chorismate-utilizing enzymes in microorganisms. Dosselaere F, Vanderleyden J;. Crit Rev Microbiol 2001;27:75-131. (from Pfam)

Date:

2024-10-16

Gene:

mbtI

Date:

2020-06-02

Members of this protein family are salicylate synthases, bifunctional enzymes that make salicylate, in two steps, from chorismate. Members are homologous to anthranilate synthase component I from Trp biosynthesis. Members typically are found in gene regions associated with siderophore or other secondary metabolite biosynthesis. Examples with context-specific names include MbtI from mycobactin biosynthesis, YbtS (Irp9) from yersiniabactin biosynthesis, and NbtS from nocobactin NA biosynthesis pathways.

Date:

2024-06-26

salicylate synthase catalyzes the initial conversion of chorismate to yield the intermediate isochorismate (isochorismate synthase activity), and the subsequent elimination of the enolpyruvyl side chain to give salicylate (isochorismate pyruvate-lyase activity)

Date:

2019-08-02