Protein Family Models

KAsynt_C_assoc represents the very C-terminus of a subset of proteins from the keto-acyl-synthetase 2 family. It is found in proteins ranging from bacteria to human. (from Pfam)

Date:

2024-08-14

This entry represents the polyketide synthase C-terminal extension from cyanobacterial CurL polyketide synthase and similar proteins from other bacteria and fungi [1-5]. Paper describing PDB structure 2hg4. [1]. 16844787. The 2.7-Angstrom crystal structure of a 194-kDa homodimeric fragment of the 6-deoxyerythronolide B synthase. Tang Y, Kim CY, Mathews II, Cane DE, Khosla C;. Proc Natl Acad Sci U S A. 2006;103:11124-11129. Paper describing PDB structure 2qo3. [2]. 17719492. Structural and mechanistic analysis of protein interactions in module 3 of the 6-deoxyerythronolide B synthase. Tang Y, Chen AY, Kim CY, Cane DE, Khosla C;. Chem Biol. 2007;14:931-943. Paper describing PDB structure 4kc5. [3]. 24048471. Vinylogous chain branching catalysed by a dedicated polyketide synthase module. Bretschneider T, Heim JB, Heine D, Winkler R, Busch B, Kusebauch B, Stehle T, Zocher G, Hertweck C;. Nature. 2013;502:124-128. Paper describing PDB structure 4mz0. [4]. 24183970. Cyanobacterial polyketide synthase docking domains: a tool for engineering natural product biosynthesis. Whicher JR, Smaga SS, Hansen DA, Brown WC, Gerwick WH, Sherman DH, Smith JL;. Chem Biol. 2013;20:1340-1351. Paper describing PDB structure 4na1. [5]. 24508341. A close look at a ketosynthase from a trans-acyltransferase modular polyketide synthase. Gay DC, Gay G, Axelrod AJ, Jenner M, Kohlhaas C, Kampa A, Oldham NJ, Piel J, Keatinge-Clay AT;. Structure. 2014;22:444-451. (from Pfam)

Date:

2024-10-16

This entry represents a linker domain found in polyketide synthases, which connects the N-terminal domains with the B-domain as described in RhiE [1-3]. Paper describing PDB structure 4kc5. [1]. 24048471. Vinylogous chain branching catalysed by a dedicated polyketide synthase module. Bretschneider T, Heim JB, Heine D, Winkler R, Busch B, Kusebauch B, Stehle T, Zocher G, Hertweck C;. Nature. 2013;502:124-128. Paper describing PDB structure 4na1. [2]. 24508341. A close look at a ketosynthase from a trans-acyltransferase modular polyketide synthase. Gay DC, Gay G, Axelrod AJ, Jenner M, Kohlhaas C, Kampa A, Oldham NJ, Piel J, Keatinge-Clay AT;. Structure. 2014;22:444-451. Paper describing PDB structure 4tkt. [3]. 26420866. Structural and evolutionary relationships of "AT-less" type I polyketide synthase ketosynthases. Lohman JR, Ma M, Osipiuk J, Nocek B, Kim Y, Chang C, Cuff M, Mack J, Bigelow L, Li H, Endres M, Babnigg G, Joachimiak A, Phillips GN Jr, Shen B;. Proc Natl Acad Sci U S A. 2015;112:12693-12698. Paper describing PDB structure 5e5n. [4]. 26724270. The LINKS motif zippers trans-acyltransferase polyketide synthase assembly lines into a biosynthetic megacomplex. Gay DC, Wagner DT, Meinke JL, Zogzas CE, Gay GR, Keatinge-Clay AT;. J Struct Biol. 2016;193:196-205. (from Pfam)

Date:

2024-10-16

The structure of beta-ketoacyl synthase is similar to that of the thiolase family (Pfam:PF00108) and also chalcone synthase. The active site of beta-ketoacyl synthase is located between the N and C-terminal domains. [1]. 9482715. Crystal structure of beta-ketoacyl-acyl carrier protein synthase II from E.coli reveals the molecular architecture of condensing enzymes. Huang W, Jia J, Edwards P, Dehesh K, Schneider G, Lindqvist Y;. EMBO J 1998;17:1183-1191. (from Pfam)

Date:

2024-10-16