The mevalonate-independent 2-C-methyl-D-erythritol 4-phosphate (MEP) pathway for isoprenoid biosynthesis is essential in many eubacteria, plants, and the malaria parasite. The LytB gene is involved in the trunk line of the MEP pathway. [1]. 8432714. Identification of the Escherichia coli lytB gene, which is involved in penicillin tolerance and control of the stringent response. Gustafson CE, Kaul S, Ishiguro EE;. J Bacteriol 1993;175:1203-1205. [2]. 11818558. Studies on the nonmevalonate terpene biosynthetic pathway: metabolic role of IspH (LytB) protein. Rohdich F, Hecht S, Gartner K, Adam P, Krieger C, Amslinger S, Arigoni D, Bacher A, Eisenreich W. Proc Natl Acad Sci U S A 2002;99:1158-11563. [3]. 11741609. Identification of (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate as a major activator for human gammadelta T cells in Escherichia coli. Hintz M, Reichenberg A, Altincicek B, Bahr U, Gschwind RM, Kollas AK, Beck E, Wiesner J, Eberl M, Jomaa H. FEBS Lett 2001;509:317-322. [4]. 11717301. The lytB gene of Escherichia coli is essential and specifies a product needed for isoprenoid biosynthesis. McAteer S, Coulson A, McLennan N, Masters M. J Bacteriol 2001;183:7403-7407. [5]. 11418107. LytB, a novel gene of the 2-C-methyl-D-erythritol 4-phosphate pathway of isoprenoid biosynthesis in Escherichia coli. Altincicek B, Kollas A, Eberl M, Wiesner J, Sanderbrand S, Hintz M, Beck E, Jomaa H. FEBS Lett 2001;499:37-40. [6]. 11004185. Evidence of a role for LytB in the nonmevalonate pathway of isoprenoid biosynthesis. Cunningham FX Jr, Lafond TP, Gantt E. J Bacteriol 2000;182:5841-5848. (from Pfam)
GO Terms:- Biological Process:
- isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway (GO:0019288)
- Molecular Function:
- metal ion binding (GO:0046872)
- Biological Process:
- dimethylallyl diphosphate biosynthetic process (GO:0050992)
- Molecular Function:
- 4-hydroxy-3-methylbut-2-enyl diphosphate reductase activity (GO:0051745)
- Date:
- 2024-10-16