Protein Family Models for Protein (Select 489519115) - Protein Family Models

Select item 4311511.

prephenate dehydrogenase dimerization domain-containing protein

Members of this family are prephenate dehydrogenases EC:1.3.1.12 (PDHs) involved in tyrosine biosynthesis [1]. This is the C-terminal, helical dimerization domain of PDHs [1]. [1]. 31750992. Structural and biochemical analysis of Bacillus anthracis prephenate dehydrogenase reveals an unusual mode of inhibition by tyrosine via the ACT domain. Shabalin IG, Gritsunov A, Hou J, Slawek J, Miks CD, Cooper DR, Minor W, Christendat D;. FEBS J. 2020;287:2235-2255. (from Pfam)

Date:: 2024-10-16

Family Accession:: NF042869.3
Method:: HMM

Select item 4154072.

NAD(P)-binding domain-containing protein

Date:: 2024-08-14

Family Accession:: NF015747.5
Method:: HMM

Select item 4143543.

NAD(P)-binding domain-containing protein

The NAD binding domain of 6-phosphogluconate dehydrogenase adopts a Rossmann fold. (from Pfam)

GO Terms:

Molecular Function:: NADP binding (GO:0050661)

Date:: 2024-08-14

Family Accession:: NF015411.5
Method:: HMM

Select item 4116114.

prephenate dehydrogenase/arogenate dehydrogenase family protein

Members of this family are prephenate dehydrogenases (PDHs) EC:1.3.1.12 involved in tyrosine biosynthesis. This is the N-terminal nucleotide-binding domain of PDHs, which has a modified Rossmann nucleotide-binding fold with an extended beta-sheet sandwiched by three helices on each face [1]. [1]. 31750992. Structural and biochemical analysis of Bacillus anthracis prephenate dehydrogenase reveals an unusual mode of inhibition by tyrosine via the ACT domain. Shabalin IG, Gritsunov A, Hou J, Slawek J, Miks CD, Cooper DR, Minor W, Christendat D;. FEBS J. 2020;287:2235-2255. (from Pfam)

GO Terms:

Biological Process:: tyrosine biosynthetic process (GO:0006571)

Molecular Function:: prephenate dehydrogenase (NAD+) activity (GO:0008977)

Molecular Function:: arogenate dehydrogenase (NADP+) activity (GO:0033730)

Molecular Function:: NAD+ binding (GO:0070403)

Date:: 2024-10-16

Family Accession:: NF014234.5
Method:: HMM

Select item 4082285.