Protein Family Models

This domain represents a DNA-binding Helix-turn-helix domain found in transcriptional regulatory proteins. (from Pfam)

Date:

2024-08-14

Members of this family contains a DNA binding 'helix-turn-helix' motif. This family includes other proteins which are not included in the Prosite definition. [1]. 9466913. Crystal structure of the cyanobacterial metallothionein repressor SmtB: a model for metalloregulatory proteins. Cook WJ, Kar SR, Taylor KB, Hall LM;. J Mol Biol 1998;275:337-346. (from Pfam)

Date:

2024-10-16

ArsR (Arsenical Resistance Operon Repressor)/SmtB family transcription factor is a winged-helix-turn-helix transcriptional regulator that may be metal-sensing and modulate the expression of genes associated with metal homeostasis

Date:

2024-04-11

BigR (biofilm growth-associated repressor) is a winged-helix DNA-binding protein active as a transcriptional regulator for Blh, a bifunctional sulfur transferase/dioxygenase found in a number of plant-associated bacteria. Oxidative conditions that allow disulfide bond formation between the invariant residues Cys42 and Cys108 cause BigR to lose DNA-binding transcriptional repressor activity.

Gene:

bigR

Date:

2021-12-29

Transcriptional repressors that sense toxic heavy metals such as arsenic or cadmium, and are released from DNA so that resistance factors will be expressed, include ArsR, SmtB, ZiaR, CadC, CadX, KmtR, etc. However, some members of this family, including the sporulation delaying system autorepressor SdpR and its family (see NF033789), may lack metal-binding cites and instead regulate other cellular processes.

Date:

2021-12-28