Protein Family Models

This entry represents the C-alpha1 domain from acyl-CoA oxidases which has an all-alpha helical structure that a forms a four-helix bundle [1-5]. This domain includes the FAD-binding and substrate-binding sites. Paper describing PDB structure 1is2. [1]. 11872165. Three-dimensional structure of the flavoenzyme acyl-CoA oxidase-II from rat liver, the peroxisomal counterpart of mitochondrial acyl-CoA dehydrogenase. Nakajima Y, Miyahara I, Hirotsu K, Nishina Y, Shiga K, Setoyama C, Tamaoki H, Miura R;. J Biochem. 2002;131:365-374. Paper describing PDB structure 1w07. [2]. 15581893. Acyl-CoA oxidase 1 from Arabidopsis thaliana. Structure of a key enzyme in plant lipid metabolism. Pedersen L, Henriksen A;. J Mol Biol. 2005;345:487-500. Paper describing PDB structure 2fon. [3]. 16699197. Structure determination and analysis of acyl-CoA oxidase (ACX1) from tomato. Powers RA, Rife CL, Schilmiller AL, Howe GA, Garavito RM;. Acta Crystallogr D Biol Crystallogr. 2006;62:683-686. Paper describing PDB structure 5k3g. [4]. 27551084. Structural characterization of acyl-CoA oxidases reveals a direct link between pheromone biosynthesis and metabolic state in Caenorhabditis elegans. Zhang X, Li K, Jones RA, Bruner SD, Butcher RA;. Proc Natl Acad Sci U S A. 2016;113:10055-10060. Paper describing PDB structure 5y9d. [5]. 29198706. Structural insight into the substrate specificity of acyl-CoA oxidase1 from Yarrowia lipolytica for short-chain dicarboxylyl-CoAs. Kim S, Kim KJ;. Biochem Biophys Res Commun. 2018;495:1628-1634. (from Pfam)

Date:

2024-10-16

this domain would appear to be the very C-terminal region of many bacterial acetyl-CoA dehydrogenases. (from Pfam)

Date:

2024-08-14

Date:

2024-08-14

The N-terminal domain of Acyl-CoA dehydrogenase is an all-alpha domain. [1]. 7857927. Three-dimensional structure of butyryl-CoA dehydrogenase from Megasphaera elsdenii. Djordjevic S, Pace CP, Stankovich MT, Kim JJ;. Biochemistry. 1995;34:2163-2171. [2]. 8356049. Crystal structures of medium-chain acyl-CoA dehydrogenase from pig liver mitochondria with and without substrate. Kim JJ, Wang M, Paschke R;. Proc Natl Acad Sci U S A 1993;90:7523-7527. (from Pfam)

Date:

2024-10-16

Central domain of Acyl-CoA dehydrogenase has a beta-barrel fold. [1]. 7857927. Three-dimensional structure of butyryl-CoA dehydrogenase from Megasphaera elsdenii. Djordjevic S, Pace CP, Stankovich MT, Kim JJ;. Biochemistry. 1995;34:2163-2171. [2]. 8356049. Crystal structures of medium-chain acyl-CoA dehydrogenase from pig liver mitochondria with and without substrate. Kim JJ, Wang M, Paschke R;. Proc Natl Acad Sci U S A 1993;90:7523-7527. (from Pfam)

Date:

2024-10-16

C-terminal domain of Acyl-CoA dehydrogenase is an all-alpha, four helical up-and-down bundle. [1]. 7857927. Three-dimensional structure of butyryl-CoA dehydrogenase from Megasphaera elsdenii. Djordjevic S, Pace CP, Stankovich MT, Kim JJ;. Biochemistry. 1995;34:2163-2171. [2]. 8356049. Crystal structures of medium-chain acyl-CoA dehydrogenase from pig liver mitochondria with and without substrate. Kim JJ, Wang M, Paschke R;. Proc Natl Acad Sci U S A 1993;90:7523-7527. [3]. 11514662. Sequence-structure analysis of FAD-containing proteins. Dym O, Eisenberg D;. Protein Sci 2001;10:1712-1728. (from Pfam)

Date:

2024-10-16

acyl-CoA dehydrogenase catalyzes the alpha,beta dehydrogenation of an acyl-CoA to form 2,3-dehydroacyl-CoA; requires an acceptor such as FAD, which becomes reduced

Date:

2023-07-12