Protein Family Models for Protein (Select 489661478) - Protein Family Models

Select item 4266571.

PDZ domain-containing protein

This entry represents the PDZ domain from a wide variety of proteins. (from Pfam)

Date:: 2024-08-14

Family Accession:: NF036497.5
Method:: HMM

Select item 4231512.

PDZ domain-containing protein

GO Terms:

Molecular Function:: protein binding (GO:0005515)

Date:: 2024-08-14

Family Accession:: NF024578.5
Method:: HMM

Select item 4126353.

site-2 protease family protein

GO Terms:

Molecular Function:: metalloendopeptidase activity (GO:0004222)

Biological Process:: proteolysis (GO:0006508)

Date:: 2024-08-14

Family Accession:: NF014244.5
Method:: HMM

Select item 4030144.

new record, indexing in progress

Family Accession:

Select item 4029835.

new record, indexing in progress

Family Accession:

Select item 3893416.

new record, indexing in progress

Family Accession:

Select item 3623897.

new record, indexing in progress

Family Accession:

Select item 3575328.

new record, indexing in progress

Family Accession:

Select item 3477019.

new record, indexing in progress

Family Accession:

Select item 5184710.

M50 family metallopeptidase

M50 family metallopeptidase cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms; belongs to the site-2 protease (S2P) class of zinc metalloproteases

Date:: 2024-09-20

Family Accession:: 11433527
Method:: Sparcle

Select item 1606711.

RIP metalloprotease RseP

Members of this nearly universal bacterial protein family are regulated intramembrane proteolysis (RIP) proteases. Older and synonymous gene symbols include yaeL in E. coli, mmpA in Caulobacter crescentus, etc. This family includes a region that hits the PDZ domain, found in a number of proteins targeted to the membrane by binding to a peptide ligand. The N-terminal region of this family contains a perfectly conserved motif HEXGH as found in a number of metalloproteinases, where the Glu is the active site and the His residues coordinate the metal cation. Membership in this family is determined by an HMM built to force a match to the full length of the seed alignment. A model that detects fragments as well matches a number of members of the PEPTIDASE FAMILY S2C. The region of match appears not to overlap the active site domain.

Gene:: rseP

GO Terms:

Molecular Function:: metalloendopeptidase activity (GO:0004222)

Biological Process:: proteolysis (GO:0006508)

Cellular Component:: membrane (GO:0016020)

Date:: 2022-10-11

Family Accession:: TIGR00054.1
Method:: HMM

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