Protein Family Models

Previously known as uncharacterized protein family UPF0015, a single member of this family Swiss:O82827 has been identified as an undecaprenyl diphosphate synthase [1]. [1]. 9677368. Molecular cloning, expression, and purification of undecaprenyl diphosphate synthase. No sequence similarity between E- and Z-prenyl diphosphate synthases. Shimizu N, Koyama T, Ogura K;. J Biol Chem 1998;273:19476-19481. (from Pfam)

Date:

2024-10-16

undecaprenyl diphosphate synthase (UPPS) family protein catalyzes consecutive condensation reactions of farnesyl diphosphate (FPP) with specific numbers of isopentenyl diphosphate (IPP) to form long-chain polyprenyl diphosphates, similar to UPPS that catalyzes chain elongation of FPP by eight IPP to form the carrier lipid UPP in bacterial cell wall peptidoglycan biosynthesis

Date:

2019-02-01

This enzyme builds undecaprenyl diphosphate, or a closely related polyprenyl diphosphate. In bacteria, the product becomes a carrier used for synthesizing cell wall components, while in the Archaea, the product is most likely a precursor of glycosyl carrier lipids. While the fine specificity varies by species, reflected in a variety of EC numbers that may be assigned (2.5.1.31, 2.5.1.86, 2.5.1.87, 2.5.1.88, 2.5.1.89, etc.), the designation UppS is widely used.

Gene:

uppS

Date:

2021-12-08

Catalyzes the formation of undecaprenyl pyrophosphate from isopentenyl pyrophosphate

Date:

2021-07-29