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sortase domain-bontaining protein
The founder member of this family is S. aureus sortase, a transpeptidase that attaches surface proteins by the threonine of an LPXTG motif to the cell wall [1]. [1]. 10427003. Staphylococcus aureus sortase, an enzyme that anchors surface proteins to the cell wall. Mazmanian SK, Liu G, Ton-That H, Schneewind O;. Science 1999;285:760-763. [2]. 11239768. An embarrassment of sortases - a richness of substrates?. Pallen MJ, Lam AC, Antonio M, Dunbar K;. Trends Microbiol 2001;9:97-102. (from Pfam)
class A sortase
class A sortase is a cysteine transpeptidase that cleaves a substrate protein at a conserved cell wall sorting signal and covalently links it to peptidoglycan and performs a housekeeping role
sortase
This family includes Staphylococcus aureus sortase A, a housekeeping transpeptidase that attaches surface proteins by the Thr of an LPXTG motif to the cell wall. The family also includes special purpose sortases required for correct assembly of LPXTG-containing fimbrial proteins. It excludes the sortase B family, for which the recognition site NPXTN is typical.
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