Protein Family Models

This small 70 amino acid domain is found duplicated in a family of bacterial proteins. These proteins may be DNA-binding transcription factors (Pers. comm. A Andreeva & A Murzin). It is likely, due to the similarity of fold, that this family acts as a bacterial antitoxin like the MazE antitoxin family. [1]. 15146477. Crystal structure of a protein associated with cell division from Mycoplasma pneumoniae (GI: 13508053): a novel fold with a conserved sequence motif. Chen S, Jancrick J, Yokota H, Kim R, Kim SH;. Proteins. 2004;55:785-791. (from Pfam)

Date:

2024-10-16

division/cell wall cluster transcriptional repressor MraZ has been implicated in the regulation of the dcw gene cluster, which contains cell division genes such as ftsZ

Date:

2024-12-19

Members of this family contain two tandem copies of a domain described by Pfam HMM PF02381. This protein often is found with other genes of the dcw (division cell wall) gene cluster, including mraW, ftsI, murE, murF, ftsW, murG, etc. Recent work shows MraW in E. coli binds an upstream region with three tandem GTGGG repeats separated by 5bp spacers. We find similar sites in other species.

Gene:

mraZ

Date:

2024-05-15