Protein Family Models for Protein (Select 489820025) - Protein Family Models

Select item 4214381.

Scavenger mRNA decapping enzyme C-term binding

This family consists of several scavenger mRNA decapping enzymes (DcpS) and is the C-terminal region. DcpS is a scavenger pyrophosphatase that hydrolyses the residual cap structure following 3' to 5' decay of an mRNA. The association of DcpS with 3' to 5' exonuclease exosome components suggests that these two activities are linked and there is a coupled exonucleolytic decay-dependent decapping pathway. The C-terminal domain contains a histidine triad (HIT) sequence with three histidines separated by hydrophobic residues. The central histidine within the DcpS HIT motif is critical for decapping activity and defines the HIT motif as a new mRNA decapping domain, making DcpS the first member of the HIT family of proteins with a defined biological function. [1]. 12198172. The scavenger mRNA decapping enzyme DcpS is a member of the HIT family of pyrophosphatases. Liu H, Rodgers ND, Jiao X, Kiledjian M;. EMBO J 2002;21:4699-4708. (from Pfam)

Date:: 2024-10-16

Family Accession:: NF023395.5
Method:: HMM

Select item 4146322.

Protein similar to CwfJ C-terminus 1

This region is found in the N terminus of Schizosaccharomyces pombe protein CwfJ (Swiss:Q09909). CwfJ is part of the Cdc5p complex involved in mRNA splicing [1]. [1]. 11884590. Proteomics analysis reveals stable multiprotein complexes in both fission and budding yeasts containing Myb-related Cdc5p/Cef1p, novel pre-mRNA splicing factors, and snRNAs. Ohi MD, Link AJ, Ren L, Jennings JL, McDonald WH, Gould KL;. Mol Cell Biol 2002;22:2011-2024. (from Pfam)

Date:: 2024-10-16

Family Accession:: NF016555.5
Method:: HMM

Select item 4115413.

HIT domain-containing protein

GO Terms:

Molecular Function:: catalytic activity (GO:0003824)

Date:: 2024-08-14

Family Accession:: NF013401.5
Method:: HMM

Select item 4012044.