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catalase-related domain-containing protein
This family represents a small conserved region within catalase enzymes (EC:1.11.1.6). All members also contain the Catalase family, Pfam:PF00199 domain. Catalase decomposes hydrogen peroxide into water and oxygen, serving to protect cells from its toxic effects [1]. This domain carries the immune-responsive amphipathic octa-peptide that is recognised by T cells [2]. [1]. 11351128. Mitochondrial catalase and oxidative injury. Bai J, Cederbaum AI;. Biol Signals Recept 2001;10:189-199. [2]. 15585332. Do Th1 or Th2 sequence motifs exist in proteins? Identification of amphipatic immunomodulatory domains in Helicobacter pylori catalase. Guy B, Krell T, Sanchez V, Kennel A, Manin C, Sodoyer R;. Immunol Lett. 2005;96:261-275. (from Pfam)
catalase
catalase splits hydrogen peroxide, which is toxic to cells, into oxygen and water; it occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide
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