Protein Family Models

The crystal structure of EutN contains a central five-stranded beta-barrel, with an alpha-helix at the open end of this barrel (PDB:2HD3). The structure also contains three additional beta-strands, which help the formation of a tight hexamer, with a hole in the center. this suggests that EutN forms a pore, with an opening of 26 Angstrom in diameter on one face and 14 Angstrom on the other face [2]. EutN is involved in the cobalamin-dependent degradation of ethanolamine [1]. [1]. 10464203. The 17-gene ethanolamine (eut) operon of Salmonella typhimurium encodes five homologues of carboxysome shell proteins. Kofoid E, Rappleye C, Stojiljkovic I, Roth J;. J Bacteriol 1999;181:5317-5329. [2]. 17588214. Functional insights from structural genomics. Forouhar F, Kuzin A, Seetharaman J, Lee I, Zhou W, Abashidze M, Chen Y, Yong W, Janjua H, Fang Y, Wang D, Cunningham K, Xiao R, Acton TB, Pichersky E, Klessig DF, Porter CW, Montelione GT, Tong L;. J Struct Funct Genomics. 2007;8:37-44. (from Pfam)

Date:

2024-10-16

EutN/CcmL family microcompartment protein assembles into multimers and forms the vertices of microcompartments, which are large proteinaceous structures, comprised of a roughly icosahedral shell and encapsulated enzymes, in which metabolism takes place

Date:

2019-11-05