Protein Family Models

This family contains several enzymes which take part in pathways involving acetyl-CoA. Acetyl-CoA hydrolase EC:3.1.2.1 (Swiss:P32316) catalyses the formation of acetate from acetyl-CoA, CoA transferase (CAT1) EC:2.8.3.- (Swiss:P38946) produces succinyl-CoA, and acetate-CoA transferase EC:2.8.3.8 (Swiss:Q59323) utilises acyl-CoA and acetate to form acetyl-CoA. [1]. 1441754. An 11.4 kb DNA segment on the left arm of yeast chromosome II carries the carboxypeptidase Y sorting gene PEP1, as well as ACH1, FUS3 and a putative ARS. Van Dyck L, Purnelle B, Skala J, Goffeau A;. Yeast 1992;8:769-776. [2]. 8550525. Molecular analysis of the anaerobic succinate degradation pathway in Clostridium kluyveri. Sohling B, Gottschalk G;. J Bacteriol 1996;178:871-880. (from Pfam)

Date:

2024-10-16

In citrate-utilising prokaryotes, citrate lyase EC:4.1.3.6 cleaves intracellular citrate into acetate and oxaloacetate, and is organised as a functional complex consisting of alpha, beta, and gamma subunits. The gamma subunit serves as an acyl carrier protein (ACP), and has a 2'-(5''-phosphoribosyl)-3'-dephospho-CoA prosthetic group. The citrate lyase is active only if this prosthetic group is acetylated; this acetylation is catalysed by an acetate:SH-citrate lyase ligase. The alpha subunit substitutes citryl for the acetyl group to form citryl-S-ACP. The beta subunit completes the reaction by cleaving the citryl to yield oxaloacetate and (regenerated) acetyl-S-ACP. This family represents the alpha subunit EC:2.8.3.10. [1]. 9457870. Purification of Leuconostoc mesenteroides citrate lyase and cloning and characterization of the citCDEFG gene cluster. Bekal S, Van Beeumen J, Samyn B, Garmyn D, Henini S, Divies C, Prevost H;. J Bacteriol 1998;180:647-654. [2]. 7830578. Klebsiella pneumoniae genes for citrate lyase and citrate lyase ligase: localization, sequencing, and expression. Bott M, Dimroth P;. Mol Microbiol 1994;14:347-356. (from Pfam)

Date:

2024-10-16

This family contains several enzymes which take part in pathways involving acetyl-CoA. Acetyl-CoA hydrolase EC:3.1.2.1 (Swiss:P32316) catalyses the formation of acetate from acetyl-CoA, CoA transferase (CAT1) EC:2.8.3.- (Swiss:P38946) produces succinyl-CoA, and acetate-CoA transferase EC:2.8.3.8 (Swiss:Q59323) utilises acyl-CoA and acetate to form acetyl-CoA. [1]. 1441754. An 11.4 kb DNA segment on the left arm of yeast chromosome II carries the carboxypeptidase Y sorting gene PEP1, as well as ACH1, FUS3 and a putative ARS. Van Dyck L, Purnelle B, Skala J, Goffeau A;. Yeast 1992;8:769-776. [2]. 8550525. Molecular analysis of the anaerobic succinate degradation pathway in Clostridium kluyveri. Sohling B, Gottschalk G;. J Bacteriol 1996;178:871-880. (from Pfam)

Date:

2024-10-16

acetyl-CoA hydrolase/transferase family protein such as Clostridium kluyveri succinyl-CoA:coenzyme A transferase, which catalyzes the formation of succinyl-CoA from succinate and acetyl-CoA, and Escherichia coli propionyl-CoA:succinate CoA transferase, which catalyzes the transfer of coenzyme A from propionyl-CoA to succinate

Date:

2018-05-16

This family of CoA transferases includes enzymes catalyzing at least two related but distinct activities. The E. coli YgfH protein has been characterized as a propionyl-CoA:succinate CoA transferase [1] where it appears to be involved in a pathway for the decarboxylation of succinate to propionate. The Clostridium kluyveri CAT1 protein has been characterized as a acetyl-CoA:succinate CoA transferase [2] and is believed to be involved in anaerobic succinate degradation. The propionate:succinate transferase activity has been reported in the propionic acid fermentation of propionibacterium species [3] where it is distinct from the coupled activities of distinct nucleotide-triphosphate dependent succinate and propionate/acetate CoA transferases (as inferred from activity in the absence of NTPs). The family represented by this model includes a member from Propionibacterium acnes KPA171202 which is likely to be responsible for this activity. A closely related clade not included in this family are the Ach1p proteins of fungi which are acetyl-CoA hydrolases [4]. This name has been applied to many of the proteins modeled by this HMM, possibly erroneously.

Date:

2021-11-04