Protein Family Models

This family of proteins forms part of the cobalt-transport complex in prokaryotes, CbiMNQO. CbiMNQO and NikMNQO are the most widespread groups of microbial transporters for cobalt and nickel ions and are unusual uptake systems as they consist of eg two transmembrane components (CbiM and CbiQ), a small membrane-bound component (CbiN) and an ATP-binding protein (CbiO) but no extracytoplasmic solute-binding protein. Similar components constitute the nickel transporters with some variability in the small membrane-bound component, either NikN or NikL, which are not similar to CbiN at the sequence level. CbiM is the substrate-specific component of the complex and is a seven-transmembrane protein [2]. The CbiMNQO and NikMNQO systems form part of the coenzyme B12 biosynthesis pathway [3]. The NikM protein is Pfam:PF10670. [1]. 8501034. Characterization of the cobalamin (vitamin B12) biosynthetic genes of Salmonella typhimurium. Roth JR, Lawrence JG, Rubenfield M, Kieffer-Higgins S, Church GM;. J Bacteriol 1993;175:3303-3316. [2]. 16352848. Comparative and functional genomic analysis of prokaryotic nickel and cobalt uptake transporters: evidence for a novel group of ATP-binding cassette transporters. Rodionov DA, Hebbeln P, Gelfand MS, Eitinger T;. J Bacteriol. 2006;188:317-327. [3]. 18174128. The complete coenzyme B12 biosynthesis gene cluster of Lactobacillus reuteri CRL1098. Santos F, Vera JL, van der Heijden R, Valdez G, de Vos WM, Sesma F, Hugenholtz J;. Microbiology. 2008;154:81-93. (from Pfam)

Date:

2024-10-16

energy-coupling factor ABC transporter permease similar to cobalt transport protein CbiM which is a seven-transmembrane protein and the substrate-specific component of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import

Date:

2019-06-17

Date:

2022-10-11

A cutoff of 200 bits for trusted orthologs of cbiM is suggested. Scores lower than 200 but higher than 20 may be considered sufficient to call a protein cobalamin biosynthesis protein CbiM-related. The seed alignment for this HMM is a cluster of very closely related proteins from Methanobacterium thermoautotrophicum, Archaeoglobus fulgidus, Methanococcus jannaschii, and Salmonella typhimurium, each of which has greater than 50% identity to all the others. The ortholog from Salmonella is the source of the gene symbol cbiM for this set. In Methanobacterium thermoautotrophicum, Archaeoglobus fulgidus, and Methanococcus jannaschii, a second homolog of cbiM is also found. These cbiM-related proteins appear to represent a distinct but less well-conserved orthologous group. Still more distant homologs include sll0383 from Synechocystis sp. and HI1621 from Haemophilus influenzae; the latter protein, from a species that does not synthesize cobalamin, is the most divergent member of the group. The functions of and relationships among the set of proteins homologous to cbiM have not been determined.

Gene:

cbiM

Date:

2024-05-30