Protein Family Models for Protein (Select 489954318) - Protein Family Models

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Items: 4

Select item 4117251.

exonuclease domain-containing protein

This family includes a variety of exonuclease proteins, such as ribonuclease T and the epsilon subunit of DNA polymerase III.; [1]. 8506149. RNase T shares conserved sequence motifs with DNA proofreading exonucleases. Koonin EV, Deutscher MP;. Nucleic Acids Res 1993;21:2521-2522. (from Pfam)

GO Terms:

Molecular Function:: exonuclease activity (GO:0004527)

Date:: 2024-10-16

Family Accession:: NF013122.5
Method:: HMM

Select item 3883482.

new record, indexing in progress

Family Accession:

Select item 3468333.

new record, indexing in progress

Family Accession:

Select item 1419464.

ribonuclease T

This HMM describes ribonuclease T, an enzyme found so far only in gamma-subdivision Proteobacteria such as Escherichia coli and Xylella fastidiosa. Ribonuclease T is homologous to the DNA polymerase III alpha chain. It can liberate AMP from the common C-C-A terminus of uncharged tRNA. It appears also to be involved in RNA maturation. It also acts as a 3' to 5' single-strand DNA-specific exonuclease; it is distinctive for its ability to remove residues near a double-stranded stem. Ribonuclease T is a high copy suppressor in E. coli of a uv-repair defect caused by deletion of three other single-stranded DNA exonucleases.