Protein Family Models

The function of this family is uncertain. The bacterial members are about 60-70 amino acids in length and the eukaryotic examples are about 120 amino acids in length. The C terminus contains the strongest conservation. Trm112p is required for tRNA methylation in S. cerevisiae and is found in complexes with 2 tRNA methylases (TRM9 and TRM11) also with putative methyltransferase YDR140W [1]. The zinc-finger protein Ynr046w is plurifunctional and a component of the eRF1 methyltransferase in yeast [2]. The crystal structure of Ynr046w has been determined to 1.7 A resolution. It comprises a zinc-binding domain built from both the N- and C-terminal sequences and an inserted domain, absent from bacterial and archaeal orthologs of the protein, composed of three alpha-helices [2]. [1]. 15899842. Trm11p and Trm112p Are both Required for the Formation of 2-Methylguanosine at Position 10 in Yeast tRNA. Purushothaman SK, Bujnicki JM, Grosjean H, Lapeyre B;. Mol Cell Biol 2005;25:4359-4370. [2]. 17008308. The zinc finger protein Ynr046w is plurifunctional and a component of the eRF1 methyltransferase in yeast. Heurgue-Hamard V, Graille M, Scrima N, Ulryck N, Champ S, van Tilbeurgh H, Buckingham RH;. J Biol Chem. 2006;281:36140-36148. (from Pfam)

Date:

2024-10-16

Gene:

ycaR

Date:

2020-10-26