Protein Family Models

This is a bacterial family of uncharacterised proteins. (from Pfam)

Date:

2024-08-14

YecH family protein is a DUF2492 domain-containing protein and probable metal-binding protein, similar to Escherichia coli protein YecH

Date:

2019-09-24

This model describes a family of small cytosolic proteins, about 80 amino acids in length, in which the eight invariant residues include three His residues and two Cys residues. Two pairs of these invariant residues occur in motifs HxH (where x is A or G) and CxH, both of which suggest metal-binding activity. Member protein BT1143 from Bacteroides thataiotaomicron was shown to be downregulated 4-fold during iron scarcity. Member protein YecH was shown to have a hyperreactive Cys, consistent with metal-binding activity. This protein family was identified by searching with a phylogenetic profile based on an anaerobic sulfatase-maturase enzyme, which contains multiple 4Fe-4S clusters. The linkages by phylogenetic profiling and by iron-sulfur cluster-related motifs together suggest this protein may be an accessory protein to certain maturases in sulfatase/maturase systems.

Date:

2023-11-03