Protein Family Models for Protein (Select 489959447) - Protein Family Models

Select item 4317071.

Ribosomal RNA large subunit methyltransferase M, N-terminal

This is the THUMP-like domain of Ribosomal RNA large subunit methyltransferase M (RLMM), adjacent the ferredoxin-like domain (Pfam:PF18125), which together constitutes the N-terminal domain [1]. RlmM specifically catalyses the 2'-O-methylation of nucleotide C2498 in the peptidyl transferase loop of 23S rRNA [1]. Paper describing PDB structure 4atn. [1]. 22923526. Crystal structure of RlmM, the 2'O-ribose methyltransferase for C2498 of Escherichia coli 23S rRNA. Punekar AS, Shepherd TR, Liljeruhm J, Forster AC, Selmer M;. Nucleic Acids Res. 2012;40:10507-10520. (from Pfam)

Date:: 2024-10-16

Family Accession:: NF045326.2
Method:: HMM

Select item 4285082.

RlmM ferredoxin-like domain

This domain is found in Ribosomal methyltransferase RlmM (YdgE) present in E. coli. RlmM catalyzes the S-adenosyl methionine (AdoMet)-dependent 2'O methylation of C2498 in 23S ribosomal RNA. The domain is ferredoxin-like and forms part of the THUMP domain which binds RNA. THUMP domains typically have low sequence similarity [1]. [1]. 22923526. Crystal structure of RlmM, the 2'O-ribose methyltransferase for C2498 of Escherichia coli 23S rRNA. Punekar AS, Shepherd TR, Liljeruhm J, Forster AC, Selmer M;. Nucleic Acids Res. 2012;40:10507-10520. (from Pfam)

Date:: 2024-10-16

Family Accession:: NF037200.5
Method:: HMM

Select item 4123973.

SAM-dependent methyltransferase

This family consists of FtsJ from various bacterial and archaeal sources FtsJ is a methyltransferase, but actually has no effect on cell division. FtsJ's substrate is the 23S rRNA. The 1.5 A crystal structure of FtsJ in complex with its cofactor S-adenosylmethionine revealed that FtsJ has a methyltransferase fold. This family also includes the N terminus of flaviviral NS5 protein. It has been hypothesised that the N-terminal domain of NS5 is a methyltransferase involved in viral RNA capping [2]. [1]. 10983982. RNA methylation under heat shock control. Bugl H, Fauman EB, Staker BL, Zheng F, Kushner SR, Saper MA, Bardwell JC, Jakob U;. Mol Cell 2000;6:349-360. [2]. 8385698. Computer-assisted identification of a putative methyltransferase domain in NS5 protein of flaviviruses and lambda 2 protein of reovirus. Koonin EV;. J Gen Virol 1993;74:733-740. (from Pfam)

GO Terms:

Molecular Function:: methyltransferase activity (GO:0008168)

Date:: 2024-10-16

Family Accession:: NF013856.5
Method:: HMM

Select item 4083274.