Protein Family Models

This enzyme repairs damaged proteins. Methionine sulfoxide in proteins is reduced to methionine. [1]. 8755589. Peptide methionine sulfoxide reductase contributes to the maintenance of adhesins in three major pathogens. Wizemann TM, Moskovitz J, Pearce BJ, Cundell D, Arvidson CG, So M, Weissbach H, Brot N, Masure HR;. Proc Natl Acad Sci USA 1996;93:7985-7990. [2]. 8700890. Cloning the expression of a mammalian gene involved in the reduction of methionine sulfoxide residues in proteins. Moskovitz J, Weissbach H, Brot N;. Proc Natl Acad Sci U S A 1996;93:2095-2099. (from Pfam)

Date:

2024-10-16

peptide-methionine (S)-S-oxide reductase catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine

Date:

2024-07-12

This HMM describes peptide methionine sulfoxide reductase (MsrA), a repair enzyme for proteins that have been inactivated by oxidation. The enzyme from E. coli is coextensive with this model and has enzymatic activity. However, in all completed genomes in which this module is present, a second protein module, described in TIGR00357, is also found, and in several cases as part of the same polypeptide chain: N-terminal to this module in Helicobacter pylori and Haemophilus influenzae (as in PilB of Neisseria gonorrhoeae) but C-terminal to it in Treponema pallidum. PilB, containing both domains, has been shown to be important for the expression of adhesins in certain pathogens.

Gene:

msrA

Date:

2021-06-02