Protein Family Models

This is family of Colbalmin-5-phosphate synthases, CobS, from bacteria. The CobS enzyme catalyses the synthesis of AdoCbl-5'-p from AdoCbi-GDP and alpha-ribazole-5'-P [1]. This enzyme is involved in the cobalamin (vitamin B12) biosynthesis pathway in particular the nucleotide loop assembly stage in conjunction with CobC, CobU and CobT [1]. [1]. 10518530. In vitro synthesis of the nucleotide loop of cobalamin by Salmonella typhimurium enzymes. Maggio-Hall LA, Escalante-Semerena JC;. Proc Natl Acad Sci U S A 1999;96:11798-11803. [2]. 8501034. Characterization of the cobalamin (vitamin B12) biosynthetic genes of Salmonella typhimurium. Roth JR, Lawrence JG, Rubenfield M, Kieffer-Higgins S, Church GM;. J Bacteriol 1993;175:3303-3316. (from Pfam)

Date:

2024-10-16

adenosylcobinamide-GDP ribazoletransferase catalyzes the formation of adenosylcobalamin from Ado-cobamide-GDP and alpha-ribazole

Date:

2022-10-26

cobS is involved with cobalamin biosynthesis in part III of colbalmin biosynthesis. The enzyme catyalzes the reactions adenosylcobinamide-GDP + alpha-ribazole-5'-P = adenosylcobalamin-5'-phosphate + GMP and adenosylcobinamide-GDP + alpha-ribazole = adenosylcobalamin + GMP. The protein product is associated with a large complex of proteins and is induced by cobinamide.

Gene:

cobS

Date:

2024-06-27