Protein Family Models for Protein (Select 490208718) - Protein Family Models

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Items: 5

Select item 4225441.

Toxin TisB, type I toxin-antitoxin system

TisB (toxicity-induced by SOS B) is an SOS-induced toxic peptide. It is a hydrophobic membrane-spanning protein which inhibits cell growth [1]. Its expression is inhibited by the antisense RNA IstR-1, which acts as an antitoxin [2]. [1]. 18761622. A small SOS-induced toxin is targeted against the inner membrane in Escherichia coli. Unoson C, Wagner EG;. Mol Microbiol. 2008;70:258-270. [2]. 15620655. The small RNA IstR inhibits synthesis of an SOS-induced toxic peptide. Vogel J, Argaman L, Wagner EG, Altuvia S;. Curr Biol. 2004;14:2271-2276. (from Pfam)

GO Terms:

Molecular Function:: monoatomic anion channel activity (GO:0005253)

Cellular Component:: plasma membrane (GO:0005886)

Biological Process:: SOS response (GO:0009432)

Biological Process:: dormancy process (GO:0022611)

Date:: 2024-10-16

Family Accession:: NF025307.5
Method:: HMM

Select item 4005942.

new record, indexing in progress

Family Accession:

Select item 3639213.

new record, indexing in progress

Family Accession:

Select item 786694.

type I toxin-antitoxin system toxin TisB

Members of this family are the TisB toxin protein of a type I toxin-antitoxin system, meaning that the antitoxin is a non-coding RNA. TisB is induced by some types of stress (SOS, ciprofloxacin) and appears to induce a persister state by dissipating transmembrane potential, thus depleting ATP. Persister cells, unable to grow until the persister state changes, survive a number of challenges, including exposure to most antibiotics.