Protein Family Models

This family includes bacterial transmembrane proteins with a putative sugar-specific permease function, including and analogous to the IIC component of the PTS system. It has been suggested that this permease may form part of an L-ascorbate utilisation pathway, with proposed specificity for 3-keto-L-gulonate (formed by hydrolysis of L-ascorbate)[1]. This family includes the IIC component of the galactitol specific GAT family PTS system. [1]. 11741871. Utilization of L-ascorbate by Escherichia coli K-12: assignments of functions to products of the yjf-sga and yia-sgb operons. Yew WS, Gerlt JA;. J Bacteriol 2002;184:302-306. (from Pfam)

Date:

2025-02-01

Date:

2020-10-26

Involved in the phosphorylation and transport of sugars across the cell membrane; protein IIA transfers a phosphoryl group to IIB which then transfers the phosphoryl group to the sugar; IIC forms the translocation channel for the sugar uptake

Date:

2020-10-26

PTS ascorbate transporter subunit IIC is part of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active transport system that catalyzes the phosphorylation of incoming substrates (such as ascorbate) concomitantly with their translocation across the cell membrane

Date:

2023-03-03

Date:

2021-09-02

Date:

2020-10-26