Protein Family Models

This group of proteins are membrane bound transport proteins essential for ferric ion uptake in bacteria [1]. The Pfam family consists of ExbD, and TolR which are involved in TonB-dependent transport of various receptor bound substrates including colicins [2]. [1]. 9371459. Unusual structure of the tonB-exb DNA region of Xanthomonas campestris pv. campestris: tonB, exbB, and exbD1 are essential for ferric iron uptake, but exbD2 is not. Wiggerich HG, Klauke B, Koplin R, Priefer UB, Puhler A;. J Bacteriol 1997;179:7103-7110. [2]. 3294803. Nucleotide sequence of a gene cluster involved in entry of E colicins and single-stranded DNA of infecting filamentous bacteriophages into Escherichia coli. Sun TP, Webster RE;. J Bacteriol 1987;169:2667-2674. (from Pfam)

Date:

2024-10-16

TonB system transport protein ExbD is involved in the TonB-dependent energy-dependent transport of various receptor-bound substrates

Date:

2018-03-09

Members of this family are Gram-negative bacterial inner membrane proteins, generally designated ExbD, related to the TolR family modeled by TIGRFAMs TIGR02801. Members always are encoded next to a protein designated ExbB (TIGR02797), related to the TolQ family modeled by TIGRFAMs TIGR02796. ExbD and ExbB together form a proton channel through which they can harness the proton-motive force to energize TonB, which in turn energizes TonB-dependent receptors in the outer membrane. TonB-dependent receptors with known specificity tend to import siderophores or vitamin B12. A TonB system and Tol-Pal system often will co-exist in a single bacterial genome.

Gene:

exbD

Date:

2024-06-14

Membrane spanning protein in TonB-ExbB-ExbD complex; involved in the tonB-independent energy-dependent transport iron-siderophore complexes and vitamin B12 into the cell

Gene:

exbD

Date:

2021-10-28