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triphosphoribosyl-dephospho-CoA synthase
The citG gene is found in a gene cluster with citrate lyase subunits [1]. The function of the CitG protein was elucidated as ATP:dephospho-CoA triphosphoribosyl transferase [2-3]. [1]. 7830578. Klebsiella pneumoniae genes for citrate lyase and citrate lyase ligase: localization, sequencing, and expression. Bott M, Dimroth P;. Mol Microbiol 1994;14:347-356. [2]. 10924139. Biosynthesis of the prosthetic group of citrate lyase. Schneider K, Dimroth P, Bott M;. Biochemistry 2000;39:9438-9450. [3]. 11042274. Identification of triphosphoribosyl-dephospho-CoA as precursor of the citrate lyase prosthetic group. Schneider K, Dimroth P, Bott M;. FEBS Lett 2000;483:165-168. (from Pfam)
triphosphoribosyl-dephospho-CoA synthase CitG
Triphosphoribosyl-dephospho-CoA is transferred to, and becomes the prosthetic group of, the respective acyl carrier protein subunits of both citrate lyase and malonate decarboxylase. Members of this protein family are triphosphoribosyl-dephospho-CoA synthases specifically from citrate lyase systems. This protein sometimes occurs as a fusion protein with CitX, the phosphoribosyl-dephospho-CoA transferase.
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