Protein Family Models for Protein (Select 490253733) - Protein Family Models

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Items: 5

Select item 4004731.

new record, indexing in progress

Family Accession:

Select item 3565622.

new record, indexing in progress

Family Accession:

Select item 1736043.

ribose 1,5-bisphosphokinase

Gene:: phnN

GO Terms:

Biological Process:: 5-phosphoribose 1-diphosphate biosynthetic process (GO:0006015)

Molecular Function:: ribose 1,5-bisphosphate phosphokinase activity (GO:0033863)

Date:: 2021-10-18

Family Accession:: NF007485.0
Method:: HMM

Select item 539324.

ribose 1,5-bisphosphokinase

ribose 1,5-bisphosphokinase catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)

Date:: 2020-10-21

Family Accession:: 10013420
Method:: Sparcle

Select item 491205.

phosphonate metabolism protein/1,5-bisphosphokinase (PRPP-forming) PhnN

Members of this family resemble PhnN of phosphonate utilization operons, where different such operons confer the ability to use somewhat different profiles of C-P bond-containing compounds (see PMID:15231805), including phosphites as well as phosphonates. PhnN in E. coli shows considerable homology to guanylate kinases (EC 2.7.4.8), and has actually been shown to act as a ribose 1,5-bisphosphokinase (PRPP forming). This suggests an analogous kinase reaction for phosphonate metabolism, converting 5-phosphoalpha-1-(methylphosphono)ribose to methylphosphono-PRPP.