Protein Family Models

Members of this family transfer activated sugars to a variety of substrates, including glycogen, fructose-6-phosphate and lipopolysaccharides. Members of the family transfer UDP, ADP, GDP or CMP linked sugars. The Glycos_transf_N region is flanked at the N-terminus by a signal peptide and at the C-terminus by Glycos_transf_1 (Pfam:PF00534). The eukaryotic glycogen synthases may be distant members of this bacterial family [1]. [1]. 10952982. 3-Deoxy-D-manno-oct-2-ulosonic acid (Kdo) transferase (WaaA) and kdo kinase (KdkA) of Haemophilus influenzae are both required to complement a waaA knockout mutation of Escherichia coli. Brabetz W, Muller-Loennies S, Brade H;. J Biol Chem 2000;275:34954-34962. (from Pfam)

Date:

2024-10-16

Mutations in this domain of Swiss:P37287 lead to disease (Paroxysmal Nocturnal haemoglobinuria). Members of this family transfer activated sugars to a variety of substrates, including glycogen, Fructose-6-phosphate and lipopolysaccharides. Members of this family transfer UDP, ADP, GDP or CMP linked sugars. The eukaryotic glycogen synthases may be distant members of this family. (from Pfam)

Date:

2024-08-14

3-deoxy-D-manno-octulosonic acid transferase catalyzes the transfer of two 3-deoxy-D-manno-octulosonate (Kdo) residues from CMP-Kdo to lipid IV(A), the tetraacyldisaccharide-1,4'-bisphosphate precursor of lipid A

Date:

2023-03-01

Gene:

waaA

Date:

2021-08-12

Gene:

waaA

Date:

2021-11-04