Protein Family Models

The structure of this domain is known and is similar to the periplasmic binding proteins [1]. This domain binds a variety of ligands that caries in size and structure, such as amino acids, sugar phosphates, organic acids, metal cations, flavonoids, C6-ring carboxylic acids, H2O2, HOCl, homocysteine, NADPH, ATP, sulphate, muropeptides, acetate, salicylate, citrate, phenol- and quinolone derivatives, acetylserines, fatty acid CoA, shikimate, chorismate, homocysteine, indole-3-acetic acid, Na(I), c-di-GMP, ppGpp and hydrogen peroxide (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043). [1]. 9309218. The structure of the cofactor-binding fragment of the LysR family member, CysB: a familiar fold with a surprising subunit arrangement. Tyrrell R, Verschueren KH, Dodson EJ, Murshudov GN, Addy C, Wilkinson AJ;. Structure 1997;5:1017-1032. (from Pfam)

Date:

2024-10-16

Date:

2024-08-14

Gene:

yieE

Date:

2022-05-12

LysR family transcriptional regulator similar to CysL which regulates sulfur metabolism in bacteria and CbbR which is part of the RuBisCO complex that regulates carbon dioxide fixation in bacteria, algae, and higher plants

Date:

2017-02-03

Date:

2020-10-26