Protein Family Models

TraF protein undergoes proteolytic processing associated with export. The 19 amino acids at the amino terminus of the polypeptides appear to constitute a typical membrane leader peptide - not included in this family, while the remainder of the molecule is predicted to be primarily hydrophilic in character [1]. F plasmid TraF and TraH are required for F pilus assembly and F plasmid transfer, and they are both localised to the outer membrane in the presence of the complete F transfer region, especially TraV, the putative anchor [2]. [1]. 3042757. The product of the F plasmid transfer operon gene, traF, is a periplasmic protein. Wu JH, Kathir P, Ippen-Ihler K;. J Bacteriol. 1988;170:3633-3639. [2]. 20081027. F plasmid TraF and TraH are components of an outer membrane complex involved in conjugation. Arutyunov D, Arenson B, Manchak J, Frost LS;. J Bacteriol. 2010;192:1730-1734. (from Pfam)

Gene:

traF

Date:

2024-10-16

This protein is related to the F-type conjugation system pilus assembly proteins TraF (TIGR02739)and TrbB (TIGR02738) both of which exhibit a thioredoxin fold [1]. The protein represented by this model has the same length and architecture as TraF, but lacks the CXXC-motif found in TrbB and believed to be responsible for the disulfide isomerase activity of that protein.

Date:

2019-09-10