Protein Family Models

This family consists of several NifT/FixU bacterial proteins. NifT/FixU is a very small, conserved protein that is found in nif clusters; however, its function is unknown [1]. Although it is thought that the protein may be involved in biosynthesis of the FeMo cofactor of nitrogenase although perturbation of nifT expression in K. pneumoniae has only a limited effect on nitrogen fixation [2]. [1]. 25513762. Regulation of Three Nitrogenase Gene Clusters in the Cyanobacterium Anabaena variabilis ATCC 29413. Thiel T, Pratte BS;. Life (Basel). 2014;4:944-967. [2]. 23308282. The NifA-RpoN regulon of Mesorhizobium loti strain R7A and its symbiotic activation by a novel LacI/GalR-family regulator. Sullivan JT, Brown SD, Ronson CW;. PLoS One. 2013;8:e53762. (from Pfam)

Date:

2024-10-16

NifT/FixU family protein may be involved in nitrogen fixation

Date:

2020-05-22

This largely uncharacterized protein family is assigned a role in nitrogen fixation by two criteria. First, its gene occurs, generally, among genes essential for expression of active nitrogenase. Second, its phylogenetic profile closely matches that of nitrogen-fixing bacteria. However, mutational studies in Klebsiella pneumoniae failed to demonstrate any phenotype for deletion or overexpression of the protein.

Gene:

nifT

Date:

2022-02-09