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sigma-S stabilization anti-adapter protein IraP
This family is conserved in Enterobacteriaceae. It is one of a series of proteins, expressed by these bacteria in response to stress, that help to regulate Sigma-S, the stationary phase sigma factor of Escherichia coli and Salmonella. IraP is essential for Sigma-S stabilisation in some but not all starvation conditions [1]. [1]. 18383615. Multiple pathways for regulation of sigmaS (RpoS) stability in Escherichia coli via the action of multiple anti-adaptors. Bougdour A, Cunning C, Baptiste PJ, Elliott T, Gottesman S;. Mol Microbiol. 2008;68:298-313. (from Pfam)
anti-adapter protein IraP
RpoS stabilzer during Pi starvation
anti-adapter protein IraP inhibits RpoS proteolysis by regulating RssB activity, thereby increasing the stability of the sigma stress factor RpoS especially during phosphate starvation, but also in stationary phase and during nitrogen starvation
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