Protein Family Models

This family includes PHO-4 from Neurospora crassa which is a is a Na(+)-phosphate symporter [1]. This family also contains the leukaemia virus receptor Swiss:Q08344. [1]. 7732001. Repressible cation-phosphate symporters in Neurospora crassa. Versaw WK, Metzenberg RL;. Proc Natl Acad Sci U S A 1995;92:3884-3887. (from Pfam)

Date:

2024-10-16

PitA is a low-affinity transporter for inorganic phosphate. It imports phosphate complexed to divalent cations such as Mg(2+) or Ca(2+). Loss of PitA function can confer reduced sensitivity to high levels of Zn(2+). The PitA of Escherichia coli has a closely related paralog, PitB, that is functional but only minimally expressed. Note that the term PitA is used broadly. This exception-level HMM identifies a rather narrow clade of PitA transporters which, however, includes both PitA and PitB of E. coli K-12.

Gene:

pitA

Date:

2021-06-28