Protein Family Models

This domain is the N-terminal Arm DNA-binding domain found in various tyrosine recombinases. (from Pfam)

Date:

2024-08-14

A family of uncharacterised proteins found by clustering human gut metagenomic sequences [1]. This family appears related to the N-terminal domain of phage integrases. [1]. 20532204. Expansion of the protein repertoire in newly explored. environments: human gut microbiome specific protein families. Ellrott K, Jaroszewski L, Weizhong L, Wooley J, Godzik, A. PLoS Computational Biology, 2010 (from Pfam)

Date:

2024-08-14

Members of this family cleave DNA substrates by a series of staggered cuts, during which the protein becomes covalently linked to the DNA through a catalytic tyrosine residue at the carboxy end of the alignment. The catalytic site residues in CRE recombinase (Swiss:P06956) are Arg-173, His-289, Arg-292 and Tyr-324. [1]. 9082984. Flexibility in DNA recombination: structure of the lambda. integrase catalytic core.. Kwon HJ, Tirumalai R, Landy A, Ellenberger T;. Science 1997;276:126-131.. [2]. 9288963. Structure of Cre recombinase complexed with DNA in a. site-specific recombination synapse.. Guo F, Gopaul DN, van Duyne GD;. Nature 1997;389:40-46. (from Pfam)

Date:

2024-08-14

tyrosine based site-specific recombinase (integrase) is involved in cleavage of a single strand of a DNA duplex by nucleophilic attack of a conserved tyrosine to give a 3' phosphotyrosyl protein-DNA adduct

Date:

2022-08-18