Protein Family Models

This family is closely related to Pfam:PF02798. (from Pfam)

Date:

2024-08-14

Date:

2024-08-14

Function: conjugation of reduced glutathione to a variety of targets. Also included in the alignment, but not GSTs: S-crystallins from squid (similarity to GST previously noted); eukaryotic elongation factors 1-gamma (not known to have GST activity and similarity not previously recognised); HSP26 family of stress-related proteins including auxin-regulated proteins in plants and stringent starvation proteins in E. coli (not known to have GST activity and similarity not previously recognised). The glutathione molecule binds in a cleft between the N- and C-terminal domains - the catalytically important residues are proposed to reside in the N-terminal domain [1]. [1]. 9680481. Three-dimensional structure of Escherichia coli glutathione S-transferase complexed with glutathione sulfonate: catalytic roles of Cys10 and His106. Nishida M, Harada S, Noguchi S, Satow Y, Inoue H, Takahashi K;. J Mol Biol 1998;281:135-147. (from Pfam)

Date:

2024-10-16

Members of this family include glutathione S-transferases, glutathione-dependent disulfide bond oxidoreductases, and some proteins not known to interact with glutathione, although most of the latter set score only a little above cutoffs for the model.

Date:

2024-10-16

Gene:

yfcG

Date:

2020-10-26