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glycosyltransferase
The sequences scoring highest to this HMM are C-terminal regions of MurG enzymes (undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase), including the UDP-GlcNAc binding site. Those enzymes belong to glycosyltransferase family 28, but lower scoring members of this family include glycosyltransferases from other families that transfer different sugars.
The glycosyltransferase family 28 includes monogalactosyldiacylglycerol synthase (Swiss:P93115, EC 2.4.1.46) and UDP-N-acetylglucosamine transferase (Swiss:P74657, EC 2.4.1.-). This N-terminal domain contains the acceptor binding site and likely membrane association site. This family also contains a large number of proteins that probably have quite distinct activities. [1]. 1649817. The murG gene of Escherichia coli codes for the UDP-N-acetylglucosamine: N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase involved in the membrane steps of peptidoglycan synthesis. Mengin-Lecreulx D, Texier L, Rousseau M, van Heijenoort J;. J Bacteriol 1991;173:4625-4636. (from Pfam)
UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase
UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase catalyzes the last step in the intracellular phase of peptidoglycan biosynthesis
undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase
RM 8449890 RT The final step of peptidoglycan subunit assembly in Escherichia coli occurs in the cytoplasm. RA Bupp K, van Heijenoort J. RL J Bacteriol 1993 Mar;175(6):1841-3
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