Protein Family Models

This entry represents the N-terminal glyoxalase-like domain found in a group of bacterial proteins, such as bleomycin resistance protein (Ble) from Klebsiella pneumoniae, lactoglutathion lyase from Haemophilus influenzae, among others. Paper describing PDB structure 1f1r. [1]. 15028678. Crystallographic comparison of manganese- and iron-dependent homoprotocatechuate 2,3-dioxygenases. Vetting MW, Wackett LP, Que L Jr, Lipscomb JD, Ohlendorf DH;. J Bacteriol. 2004;186:1945-1958. Paper describing PDB structure 1han. [2]. 7481800. Crystal structure of the biphenyl-cleaving extradiol dioxygenase from a PCB-degrading pseudomonad. Han S, Eltis LD, Timmis KN, Muchmore SW, Bolin JT;. Science 1995;270:976-980. Paper describing PDB structure 2c21. [3]. 18826259. Intermediate in the O-O bond cleavage reaction of an extradiol dioxygenase. Kovaleva EG, Lipscomb JD;. Biochemistry. 2008;47:11168-11170. Paper describing PDB structure 4ghc. [4]. 23066739. Structural basis for the role of tyrosine 257 of homoprotocatechuate 2,3-dioxygenase in substrate and oxygen activation. Kovaleva EG, Lipscomb JD;. Biochemistry. 2012;51:8755-8763. [5]. 11134052. Crystal structures of the transposon Tn5-carried bleomycin resistance determinant uncomplexed and complexed with bleomycin. Maruyama M, Kumagai T, Matoba Y, Hayashida M, Fujii T, Hata Y, Sugiyama M;. J Biol Chem. 2001;276:9992-9999. (from Pfam)

Date:

2024-10-16

Date:

2024-08-14

vicinal oxygen chelate (VOC) family protein uses a metal center to coordinate a substrate, intermediate, or transition state through vicinal oxygen atoms

Date:

2024-05-13