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pyrimidine dimer DNA glycosylase/endonuclease V
Pyrimidine dimer DNA glycosylases excise pyrimidine dimers by hydrolysis of the glycosylic bond of the 5' pyrimidine, followed by the intra-pyrimidine phosphodiester bond. Pyrimidine dimers are the major UV-lesions of DNA. [1]. 1575827. X-ray structure of T4 endonuclease V: an excision repair enzyme specific for a pyrimidine dimer. Morikawa K, Matsumoto O, Tsujimoto M, Katayanagi K, Ariyoshi M, Doi T, Ikehara M, Inaoka T, Ohtsuka E;. Science 1992;256:523-526. (from Pfam)
pyrimidine dimer DNA glycosylase/endonuclease V participates in the repair of UV-damaged DNA by excising pyrimidine dimers that are the major UV-lesions, and has DNA glycosylase activity, hydrolyzing the glycosylic bond of the 5' pyrimidine of the dimer
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