Protein Family Models

This model was built to identify the lid domain of HdaA, a DnaA homolog that acts in the regulatory inactivation of DnaA. However, in a number of species, this HMM has two qualifying his, a strong one to HdaA, and a much weaker hit to DnaA that just manages to exceed the gathering thresholds.

Date:

2024-10-28

This family of proteins represents the N-terminal domain of DnaA, a protein involved in the initiation of bacterial chromosomal replication. The structure of this domain is known [1]. It is also found in three copies in some proteins such as Swiss:B5V0X4. The exact function of this domain is uncertain but it has been suggested to play a role in oligomerisation. [1]. 17680349. NMR structure of the N-terminal domain of the replication initiator protein DnaA. Lowery TJ, Pelton JG, Chandonia JM, Kim R, Yokota H, Wemmer DE;. J Struct Funct Genomics. 2007;8:11-17. (from Pfam)

Date:

2024-10-16

Date:

2024-08-14

This protein contains an ATP/GTP binding P-loop motif. It is found associated with IS21 family insertion sequences [1]. The function of this protein is unknown, but it may perform a transposase function [2]. [1]. 7698671. Characterization and sequence of a novel insertion sequence, IS1162, from Pseudomonas fluorescens. Solinas F, Marconi AM, Ruzzi M, Zennaro E;. Gene 1995;155:77-82. [2]. 9141667. Characterization of IS1474, an insertion sequence of the IS21 family isolated from Pseudomonas alcaligenes NCIB 9867. Yeo CC, Poh CL;. FEMS Microbiol Lett 1997;149:257-263. (from Pfam)

Date:

2024-10-16

This entry represents the ATPAse domain of DnaA and similar proteins. [1]. 12234917. The structure of bacterial DnaA: implications for general mechanisms underlying DNA replication initiation. Erzberger JP, Pirruccello MM, Berger JM;. EMBO J. 2002;21:4763-4773. (from Pfam)

Date:

2024-10-16

AAA family proteins often perform chaperone-like functions that assist in the assembly, operation, or disassembly of protein complexes [2]. [1]. 7646486. A 200-amino acid ATPase module in search of a basic function. Confalonieri F, Duguet M;. Bioessays 1995;17:639-650. A large extension of the family. [2]. 9927482. AAA+: A class of chaperone-like ATPases associated with the assembly, operation, and disassembly of protein complexes. Neuwald AF, Aravind L, Spouge JL, Koonin EV;. Genome Res 1999;9:27-43. (from Pfam)

Date:

2024-10-16

chromosomal replication initiator protein DnaA plays a key role in the initiation and regulation of chromosomal replication

Date:

2024-12-05

DnaA binds to the dnaA-box as an ATP-bound complex at the origin of replication during the initiation of chromosomal replication. It can also affect transcription of multiple genes including itself. is involved in DNA biosynthesis; initiation of chromosome replication and can also be transcription regulator. The C-terminal of the family hits the pfam bacterial DnaA (bac_dnaA) domain family. For a review, see Kaguni (2006).

Gene:

dnaA

Date:

2021-04-27