Protein Family Models for Protein (Select 490724965) - Protein Family Models

Select item 4134201.

TrkA C-terminal domain-containing protein

This domain is often found next to the Pfam:PF02254 domain. The exact function of this domain is unknown. It has been suggested that it may bind an unidentified ligand [1]. The domain is predicted to adopt an all beta structure [1]. [1]. 11292341. Regulatory potential, phyletic distribution and evolution of ancient, intracellular small-molecule-binding domains. Anantharaman V, Koonin EV, Aravind L;. J Mol Biol 2001;307:1271-1292. (from Pfam)

GO Terms:

Biological Process:: potassium ion transport (GO:0006813)

Molecular Function:: monoatomic cation transmembrane transporter activity (GO:0008324)

Date:: 2024-10-16

Family Accession:: NF014171.5
Method:: HMM

Select item 4114012.

cation:proton antiporter

Na/H antiporters are key transporters in maintaining the pH of actively metabolising cells. The molecular mechanisms of antiport are unclear. These antiporters contain 10-12 transmembrane regions (M) at the amino-terminus and a large cytoplasmic region at the carboxyl terminus. The transmembrane regions M3-M12 share identity with other members of the family. The M6 and M7 regions are highly conserved. Thus, this is thought to be the region that is involved in the transport of sodium and hydrogen ions. The cytoplasmic region has little similarity throughout the family. [1]. 9537504. Comparative molecular analysis of Na+/H+ exchangers: a unified model for Na+/H+ antiport?. Dibrov P, Fliegel L;. FEBS Lett 1998;424:1-5. [2]. 9278382. Na+/H+ exchangers of mammalian cells. Orlowski J, Grinstein S;. J Biol Chem 1997;272:22373-22376. [3]. 9507001. Identification of a mitochondrial Na+/H+ exchanger. Numata M, Petrecca K, Lake N, Orlowski J;. J Biol Chem 1998;273:6951-6959. (from Pfam)

GO Terms:

Biological Process:: monoatomic cation transport (GO:0006812)

Molecular Function:: antiporter activity (GO:0015297)

Cellular Component:: membrane (GO:0016020)

Biological Process:: transmembrane transport (GO:0055085)

Biological Process:: proton transmembrane transport (GO:1902600)

Date:: 2024-10-16

Family Accession:: NF013188.5
Method:: HMM

Select item 3902503.

new record, indexing in progress

Family Accession:

Select item 3894404.

new record, indexing in progress

Family Accession:

Select item 3482155.

new record, indexing in progress

Family Accession:

Select item 3465746.

new record, indexing in progress

Family Accession:

Select item 2098827.

potassium/proton antiporter

potassium/proton antiporter extrudes potassium in exchange for external protons and maintains the internal concentration of potassium under toxic levels

Date:: 2018-02-09

Family Accession:: 11461656
Method:: Sparcle

Select item 350758.

potassium/proton antiporter

Date:: 2020-10-26

Family Accession:: NF003715.0
Method:: HMM

Select item 343519.

potassium/proton antiporter

GO Terms:

Biological Process:: potassium ion transport (GO:0006813)

Molecular Function:: monoatomic cation transmembrane transporter activity (GO:0008324)

Cellular Component:: membrane (GO:0016020)

Date:: 2022-10-11

Family Accession:: NF003716.0
Method:: HMM

Select item 3435010.

potassium/proton antiporter

GO Terms:

Biological Process:: potassium ion transport (GO:0006813)

Biological Process:: cell volume homeostasis (GO:0006884)

Cellular Component:: membrane (GO:0016020)

Molecular Function:: metal cation:proton antiporter activity (GO:0051139)

Biological Process:: transmembrane transport (GO:0055085)

Date:: 2022-12-21

Family Accession:: NF003714.0
Method:: HMM

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