Protein Family Models

Members of this family are integral membrane proteins that are involved in transport of nicotinamide mononucleotide [1,2]. [1]. 2198247. Regulation of NAD metabolism in Salmonella typhimurium: molecular sequence analysis of the bifunctional nadR regulator and the nadA-pnuC operon. Foster JW, Park YK, Penfound T, Fenger T, Spector MP;. J Bacteriol 1990;172:4187-4196. [2]. 2546921. Genetic characterization of the pnuC gene, which encodes a component of the nicotinamide mononucleotide transport system in Salmonella typhimurium. Zhu N, Olivera BM, Roth JR;. J Bacteriol 1989;171:4402-4409. (from Pfam)

Date:

2024-10-16

The PnuC protein of E. coli is membrane protein responsible for nicotinamide mononucleotide transport, subject to regulation by interaction with the NadR (also called NadI) protein (see TIGR01526). This HMM defines a region corresponding to most of the length of PnuC, found primarily in pathogens. The extreme N- and C-terminal regions are poorly conserved and not included in the alignment and model.

Gene:

pnuC

Date:

2022-10-11

nicotinamide riboside transporter PnuC is involved in the transport of nicotinamide ribonucleoside across the inner membrane

Date:

2021-04-23