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Links from Protein

Items: 12

1.

Formamidopyrimidine-DNA glycosylase H2TH domain

Formamidopyrimidine-DNA glycosylase (Fpg) is a DNA repair enzyme that excises oxidised purines from damaged DNA. This family is the central domain containing the DNA-binding helix-two turn-helix domain [1]. [1]. 11912217. Structure of formamidopyrimidine-DNA glycosylase covalently complexed to DNA. Gilboa R, Zharkov DO, Golan G, Fernandes AS, Gerchman SE, Matz E, Kycia JH, Grollman AP, Shoham G;. J Biol Chem 2002;277:19811-19816. (from Pfam)

GO Terms:
Molecular Function:
damaged DNA binding (GO:0003684)
Molecular Function:
DNA-(apurinic or apyrimidinic site) endonuclease activity (GO:0003906)
Biological Process:
base-excision repair (GO:0006284)
Molecular Function:
zinc ion binding (GO:0008270)
Molecular Function:
hydrolase activity, hydrolyzing N-glycosyl compounds (GO:0016799)
Date:
2024-10-16

Family Accession:
NF018533.5
Method:
HMM

2.

zinc finger domain-containing protein

This zinc binding domain is found at the C-terminus of isoleucyl tRNA synthetase and the enzyme Formamidopyrimidine-DNA glycosylase EC:3.2.2.23. (from Pfam)

GO Terms:
Molecular Function:
zinc ion binding (GO:0008270)
Date:
2024-08-14

Family Accession:
NF018531.5
Method:
HMM

3.

DNA-formamidopyrimidine glycosylase family protein

Formamidopyrimidine-DNA glycosylase (Fpg) is a DNA repair enzyme that excises oxidised purines from damaged DNA. This family is the N-terminal domain contains eight beta-strands, forming a beta-sandwich with two alpha-helices parallel to its edges [1]. [1]. 11912217. Structure of formamidopyrimidine-DNA glycosylase covalently complexed to DNA. Gilboa R, Zharkov DO, Golan G, Fernandes AS, Gerchman SE, Matz E, Kycia JH, Grollman AP, Shoham G;. J Biol Chem 2002;277:19811-19816. (from Pfam)

GO Terms:
Molecular Function:
DNA-(apurinic or apyrimidinic site) endonuclease activity (GO:0003906)
Biological Process:
base-excision repair (GO:0006284)
Molecular Function:
zinc ion binding (GO:0008270)
Molecular Function:
DNA N-glycosylase activity (GO:0019104)
Date:
2024-10-16

Family Accession:
NF013328.5
Method:
HMM

4.
new record, indexing in progress
Family Accession:
5.
new record, indexing in progress
Family Accession:
6.
new record, indexing in progress
Family Accession:
7.
new record, indexing in progress
Family Accession:
8.
new record, indexing in progress
Family Accession:
9.
new record, indexing in progress
Family Accession:
10.

Fpg/Nei family DNA glycosylase

Fpg/Nei family DNA glycosylase similar to Escherichia coli DNA-formamidopyrimidine glycosylase (Fpg), a DNA repair enzyme that excises oxidized purines from damaged DNA

Date:
2024-08-28

Family Accession:
11479425
Method:
Sparcle

11.

bifunctional DNA-formamidopyrimidine glycosylase/DNA-(apurinic or apyrimidinic site) lyase

Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents; acts as DNA glycosylase that recognizes and removes damaged bases

Gene:
mutM
GO Terms:
Molecular Function:
nucleic acid binding (GO:0003676)
Molecular Function:
damaged DNA binding (GO:0003684)
Molecular Function:
DNA-(apurinic or apyrimidinic site) endonuclease activity (GO:0003906)
Biological Process:
DNA repair (GO:0006281)
Biological Process:
base-excision repair (GO:0006284)
Molecular Function:
zinc ion binding (GO:0008270)
Molecular Function:
oxidized purine nucleobase lesion DNA N-glycosylase activity (GO:0008534)
Molecular Function:
hydrolase activity, hydrolyzing N-glycosyl compounds (GO:0016799)
Molecular Function:
DNA N-glycosylase activity (GO:0019104)
Date:
2021-07-22

Family Accession:
NF002211.1
Method:
HMM

12.

DNA-formamidopyrimidine glycosylase

All proteins in the FPG family with known functions are FAPY-DNA glycosylases that function in base excision repair. Homologous to endonuclease VIII (nei). This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University).

Gene:
mutM
GO Terms:
Cellular Component:
cytoplasm (GO:0005737)
Biological Process:
DNA repair (GO:0006281)
Molecular Function:
oxidized purine nucleobase lesion DNA N-glycosylase activity (GO:0008534)
Molecular Function:
metal ion binding (GO:0046872)
Date:
2024-05-30

Family Accession:
TIGR00577.1
Method:
HMM

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