Protein Family Models for Protein (Select 490801826) - Protein Family Models

Select item 4258261.

This domain is found in Enoyl-(Acyl carrier protein) reductases. (from Pfam)

Date:: 2024-08-14

Family Accession:: NF024950.5
Method:: HMM

Select item 4213452.

This enzymatic domain is part of bacterial polyketide synthases and catalyses the first step in the reductive modification of the beta-carbonyl centres in the growing polyketide chain. It uses NADPH to reduce the keto group to a hydroxy group [1]. [1]. 23790488. Structural and stereochemical analysis of a modular polyketide synthase ketoreductase domain required for the generation of a cis-alkene. Bonnett SA, Whicher JR, Papireddy K, Florova G, Smith JL, Reynolds KA;. Chem Biol. 2013;20:772-783. (from Pfam)

Date:: 2024-10-16

Family Accession:: NF020243.5
Method:: HMM

Select item 4197153.

DUF1776 domain-containing protein

This is a fungal family of unknown function. One of the proteins in this family Swiss:P32792 has been localised to the mitochondria [1]. [1]. 14576278. The proteome of Saccharomyces cerevisiae mitochondria. Sickmann A, Reinders J, Wagner Y, Joppich C, Zahedi R, Meyer HE, Schonfisch B, Perschil I, Chacinska A, Guiard B, Rehling P, Pfanner N, Meisinger C;. Proc Natl Acad Sci U S A. 2003;100:13207-13212. (from Pfam)

Date:: 2024-10-16

Family Accession:: NF020227.5
Method:: HMM

Select item 4123804.

NAD-dependent epimerase/dehydratase family protein

This family of proteins utilise NAD as a cofactor. The proteins in this family use nucleotide-sugar substrates for a variety of chemical reactions. [1]. 9174344. Structural analysis of UDP-sugar binding to UDP-galactose 4-epimerase from Escherichia coli. Thoden JB, Hegeman AD, Wesenberg G, Chapeau MC, Frey PA, Holden HM;. Biochemistry 1997;36:6294-6304. (from Pfam)

GO Terms:

Molecular Function:: catalytic activity (GO:0003824)

Date:: 2024-10-16

Family Accession:: NF013530.5
Method:: HMM

Select item 4113075.

SDR family NAD(P)-dependent oxidoreductase

This family contains a wide variety of dehydrogenases. [1]. 9735295. The refined crystal structure of Drosophila lebanonensis alcohol dehydrogenase at 1.9 A resolution. Benach J, Atrian S, Gonzalez-Duarte R, Ladenstein R;. J Mol Biol 1998;282:383-399. [2]. 10387002. Structure of tropinone reductase-II complexed with NADP+ and pseudotropine at 1.9 A resolution: implication for stereospecific substrate binding and catalysis. Yamashita A, Kato H, Wakatsuki S, Tomizaki T, Nakatsu T, Nakajima K, Hashimoto T, Yamada Y, Oda J;. Biochemistry 1999;38:7630-7637. (from Pfam)

Date:: 2024-10-16

Family Accession:: NF012334.5
Method:: HMM

Select item 4000276.