Protein Family Models

This family of enzymes are a a large metal dependent hydrolase superfamily [1]. The family includes Adenine deaminase EC:3.5.4.2 that hydrolyses adenine to form hypoxanthine and ammonia. Adenine deaminases reaction is important for adenine utilisation as a purine and also as a nitrogen source [2]. This family also includes dihydroorotase and N-acetylglucosamine-6-phosphate deacetylases, EC:3.5.1.25 These enzymes catalyse the reaction N-acetyl-D-glucosamine 6-phosphate + H2O <=> D-glucosamine 6-phosphate + acetate. This family includes the catalytic domain of urease alpha subunit [3]. Dihydroorotases (EC:3.5.2.3) are also included [4-5]. [1]. 9144792. An evolutionary treasure: unification of a broad set of. amidohydrolases related to urease.. Holm L, Sander C;. Proteins 1997;28:72-82.. [2]. 8550522. Role of adenine deaminase in purine salvage and nitrogen. metabolism and characterization of the ade gene in Bacillus. subtilis.. Nygaard P, Duckert P, Saxild HH;. J Bacteriol 1996;178:846-853.. [3]. 7754395. The crystal structure of urease from Klebsiella aerogenes.. Jabri E, Carr MB, Hausinger RP, Karplus PA;. Science 1995;268:998-1004.. [4]. 9878395. Novel organization and sequences of five genes encoding all six. enzymes for de novo pyrimidine biosynthesis in Trypanosoma. cruzi.. Gao G, Nara T, Nakajima-Shimada J, Aoki T;. J Mol Biol 1999;285:149-161.. [5]. 8590465. As in Saccharomyces cerevisiae, aspartate transcarbamoylase is. assembled on a multifunctional protein including a. dihydroorotase-like cryptic domain in Schizosaccharomyces pombe.. Lollier M, Jaquet L, Nedeva T, Lacroute F, Potier S, Souciet JL;. Curr Genet 199. TRUNCATED at 1650 bytes (from Pfam)

Date:

2024-08-14

This HMM represents the D-hydantoinase (dihydropyrimidinase) which primarily converts 5,6-dihydrouracil to 3-ureidopropanoate but also acts on dihydrothymine and hydantoin. The enzyme is a metalloenzyme [1].

Gene:

hydA

Date:

2024-05-30

dihydropyrimidinase catalyzes the hydrolysis of dihydropyrimidines and of the structurally related DL-5-mono-substituted hydantoins, to produce N-carbamoyl-D-amino acids

Date:

2018-04-24