Protein Family Models

This family comprises the C-terminal portion of proteins that belong to the TetR family of transcriptional regulators. The C terminus represents the regulatory region, and does not include the DNA binding helix-turn-helix domain. The target proteins that are repressed are involved in the transcriptional control of multi-drug efflux pumps, pathways for the biosynthesis of antibiotics, response to osmotic stress and toxic chemicals, control of catabolic pathways, differentiation processes, and pathogenicity [1]. One of the target proteins is BetI, an osmoprotectant which controls the choline-glycine betaine pathway in E.coli [2]. [1]. 15944459. The TetR family of transcriptional repressors. Ramos JL, Martinez-Bueno M, Molina-Henares AJ, Teran W, Watanabe K, Zhang X, Gallegos MT, Brennan R, Tobes R;. Microbiol Mol Biol Rev. 2005;69:326-356. [2]. 1431248. Growth of Escherichia coli in human urine: role of salt tolerance and accumulation of glycine betaine. Kunin CM, Hua TH, Van Arsdale White L, Villarejo M;. J Infect Dis. 1992;166:1311-1315. (from Pfam)

Date:

2024-10-16

Date:

2024-08-14

transcriptional regulator BetI is a DNA-binding transcriptional repressor of the bet (betaine) regulon

Date:

2023-03-13

BetI is a DNA-binding transcriptional repressor of the bet (betaine) regulon. In sequence, it is related to TetR (PF00440). Choline, through BetI, induces the expression of the betaine biosynthesis genes betA and betB by derepression. The choline porter gene betT is also part of this regulon in Escherichia coli. Note that a different transcriptional regulator, ArcA, controls the expression of bet regulon genes in response to oxygen, as BetA is an oxygen-dependent enzyme.

Gene:

betI

Date:

2024-09-06

HTH-type; bet1; Repressor involved in choline regulation of the bet genes

Gene:

betI

Date:

2021-08-24